Full Description
A family of membrane glycoproteins variably expressed on all hematopoietic cells, including lymphocytes, monocytes, and eosinophils, but absent on normal and malignant non-hematopoietic tissues. Aberrant loss of CD45 expression occurs in some precursor B-lymphoblastic leukemias, most multiple myelomas, and nearly all cases of classical Hodgkin lymphoma, where Reed-Sternberg cells and their variants are typically negative.
Methodology
IHC
Specimen Requirements
Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.
Storage and Transportation
Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.
Turnaround Time
24 Hrs
CPT Codes
88342x1 or 88341x1