IHC

CD4

A cell surface protein highly expressed on helper T cells and at lower levels on monocytes, Langerhans cells, and dendritic cells. Absent in immature thymocytes. Most mature T-cell lymphomas are positive, except aggressive NK-cell leukemia, extranodal NK/T-cell lymphoma, γδ T-cell lymphomas, and enteropathy-associated T-cell lymphoma. Functions as the HIV receptor.

Full Description

A cell surface protein highly expressed on helper T cells and at lower levels on monocytes, Langerhans cells, and dendritic cells. Absent in immature thymocytes. Most mature T-cell lymphomas are positive, except aggressive NK-cell leukemia, extranodal NK/T-cell lymphoma, γδ T-cell lymphomas, and enteropathy-associated T-cell lymphoma. Functions as the HIV receptor.

Methodology

IHC

Specimen Requirements

Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

Turnaround Time

24 hrs

CPT Codes

88342x1 or 88341x1