IHC

CD123

Identifies the interleukin-3 receptor and labels plasmacytoid dendritic cells. It is useful in diagnosing neoplasms derived from these cells and is also expressed at variable intensity in all classical hairy cell leukemia, most B-ALLs, and in a subset of AMLs. It is also useful for diagnosing reactive conditions such as histiocytic necrotizing lymphadentis.

Full Description

Identifies the interleukin-3 receptor and labels plasmacytoid dendritic cells. It is useful in diagnosing neoplasms derived from these cells and is also expressed at variable intensity in all classical hairy cell leukemia, most B-ALLs, and in a subset of AMLs. It is also useful for diagnosing reactive conditions such as histiocytic necrotizing lymphadentis.

Methodology

IHC

Specimen Requirements

Tissue Block: Formalin-fixed, paraffin-embedded (FFPE) tumor block preferred. Unstained Slides: Recommended 2 charged slides per stain requested (minimum of 1 slide per stain), baked or unbaked. Fixation: Tissue must be fixed in 10% neutral buffered formalin for 6–72 hours.

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

Turnaround Time

24 Hrs

CPT Codes

88342x1 or 88341x1