Molecular

CALR Mutation Analysis

PCR assay for fragment analysis of exon 9 of the CALR (calreticulin) gene for enhanced detection of low levels of insertion/deletion mutations, which generally appear to be mutually exclusive with JAK2 and MPL mutations. This aids in the specific diagnosis of a myeloproliferative neoplasm and distinguishes from a benign reactive process.

Full Description

PCR assay for fragment analysis of exon 9 of the CALR (calreticulin) gene for enhanced detection of low levels of insertion/deletion mutations, which generally appear to be mutually exclusive with JAK2 and MPL mutations. This aids in the specific diagnosis of a myeloproliferative neoplasm and distinguishes from a benign reactive process.

Methodology

Molecular

Specimen Requirements

Whole blood (3-5 mL), Bone marrow(1-2 mL), in Lavender-top (EDTA) tube.

Storage and Transportation

Use cold pack for transport but not in direct contact with specimen. Ship same day as drawn whenever possible.

Turnaround Time

10 days

CPT Codes

81219