Molecular

BRCA1/2 Mutation Analysis for Tumors

Next-generation sequencing assay to analyze mutations of all coding exons of the BRCA1 and BRCA2genes including point mutations and small insertions/deletions, which can lead to an increased risk of cancers, particularly breast and ovarian cancer. This test does not detect large deletions or duplications.

Full Description

Next-generation sequencing assay to analyze mutations of all coding exons of the BRCA1 and BRCA2genes including point mutations and small insertions/deletions, which can lead to an increased risk of cancers, particularly breast and ovarian cancer. This test does not detect large deletions or duplications.

Methodology

Molecular

Specimen Requirements

Formalin-fixed, paraffin-embedded(FFPE) tissue block (preferred, 40% tumor or more) or slides (1 H&E slide,plus 5-10 unstained slides cut at 5+ microns. Please use positively-charged slides and 10% NBF fixative. Do not use zinc fixatives.

Storage and Transportation

Use cold pack for transport. Make sure cold pack is not in direct contact with specimen.

Turnaround Time

14 days

CPT Codes

81163